Hypertension complicated by hyperlipidemia Drug guidance:
Hypercholesterolemia and hypertension are often two interrelated diseases. In a survey of 51 million hypertensive patients in the United States, it was found that 40% of patients had a serum total cholesterol level higher than 62 mmol / L, while 46% of hypercholesterolemic patients with a serum total cholesterol level higher than 6.2 mmol / l also had hypertension. The higher the blood pressure, the greater the risk of coronary heart disease. The increase of serum total cholesterol level will have a synergistic effect on the risk of coronary heart disease in patients with hypertension. However, lowering blood pressure and serum total cholesterol levels can reduce the risk of coronary heart disease.
Cholic acid chelators, nicotinic acid and its derivatives, fibric acid derivatives and statins can be used to treat patients with hyperlipidemia and hypertension. But when using these lipid-lowering drugs, we should pay attention to the interaction between them and antihypertensive drugs. Bile acid chelators can reduce the absorption of thiazide diuretics and propranolol (propranolol). Therefore, these antihypertensive drugs must be used 1 hour before or 4 hours after taking bile acid chelators.
It should be noted that nicotinic acid can enhance the vasodilatory effect of antihypertensive drugs, which leads to the decrease of blood pressure. Fibric acid derivatives may cause myopathy in some patients with renal failure. Therefore, the dose of such drugs should be small, and patients should be followed up regularly. There is no special interaction between statins and antihypertensive drugs, which can be used to treat patients with hyperlipidemia and hypertension. In addition, there is no special interaction between lipid-lowering drugs such as dosenkang, fish oil lipid-lowering pills and antihypertensive drugs, which can also be used for lipid-lowering treatment of patients with hyperlipidemia and hypertension.
When choosing antihypertensive drugs, they should be matched reasonably. Long term use of diuretics and some antihypertensive drugs containing diuretic components, such as hydrochlorothiazide (hydrochlorothiazide), compound antihypertensive tablets, may lead to increased blood lipids. While long-term use β Receptor blockers, such as propranolol (propranolol), may also increase the level of triacylglycerol. Therefore, hypertensive patients with high blood lipids should choose a new generation of antihypertensive drugs under the guidance of doctors, such as amlodipine, captopril, benazepril, etc. these drugs can stabilize blood pressure for 24 hours, do not affect blood lipid metabolism, and have protective effects on heart, brain, and kidney.
hypertension complicated by hyperlipidemia poses significant risks to an individual’s health.
The primary concerns are related to the increased risk of cardiovascular diseases, which can have severe and potentially life-threatening consequences. Here are some of the key dangers associated with this dual condition:
- Cardiovascular Events: The combination of high blood pressure and high cholesterol significantly increases the risk of cardiovascular events such as heart attacks and strokes. High blood pressure can damage the arteries, making them less flexible and more prone to the buildup of fatty deposits. High cholesterol contributes to the formation of these deposits (plaque), which can narrow the arteries and reduce blood flow to the heart and brain.
- Heart Disease: Over time, the strain on the heart caused by high blood pressure, coupled with the effects of high cholesterol, can lead to the development of heart disease. This includes conditions such as coronary artery disease, heart failure, and irregular heartbeats (arrhythmias).
- Kidney Damage: High blood pressure can damage the kidneys, reducing their ability to filter waste from the blood effectively. High cholesterol can also contribute to kidney problems by affecting the blood vessels in the kidneys.
- Peripheral Vascular Disease: This condition involves the narrowing of blood vessels outside of the heart and brain, often in the legs. It can cause pain, numbness, or weakness in the limbs and can increase the risk of amputation if left untreated.
- Cognitive Decline: The reduced blood flow to the brain caused by high blood pressure and high cholesterol can contribute to cognitive decline and an increased risk of dementia.
- Eye Damage: High blood pressure can damage the blood vessels in the eyes, leading to vision problems or even blindness. High cholesterol can also contribute to eye conditions by affecting the blood vessels in the eyes.
- Metabolic Syndrome: The coexistence of high blood pressure and high cholesterol is often part of a cluster of conditions known as metabolic syndrome, which also includes high blood sugar, excess abdominal fat, and abnormal cholesterol levels. This syndrome significantly increases the risk of type 2 diabetes and cardiovascular disease.
In summary, the combined effects of high blood pressure and high cholesterol can lead to a wide range of serious health issues, making it crucial to manage both conditions effectively through lifestyle changes, medication, and regular medical monitoring.
